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CVG 2022 Seminar-6: X-ray Crystallography for Pharmaceuticals
July 21, 2022 @ 5:30 pm to 6:30 pm
Speaker: Dr. Jim Britten and Vicky Jarvis
Seminar will be conducted online via Zoom @ 5:30 pm EDT
In this presentation we will take a quick look at the process of X-ray diffraction from crystalline materials. We will demonstrate the process of determining the structure and absolute configuration of an organic molecule using single crystal analysis. We will use powder diffraction for phase ID, polymorph differentiation, stability studies, and impurity detection. We will illustrate different sample forms that can be used for 2D diffraction experiments. Finally, we look at X-ray scattering from amorphous phases.
Jim Britten received his PhD from McMaster University in 1984. After an NSERC postdoc at the Université de Montréal and a Killam postdoc at Dalhousie University, he became the crystallographer for the McGill Chemistry Department. In 1991 he became the Manager of the McMaster X-ray Facility, Jim has served as the Chair of the Canadian National Committee for Crystallography and as a member of Council for the American Crystallographic Association (ACA). He is a Fellow of the ACA. He was Chair of the Program Committee for the 2014 International Union of Crystallography Congress in Montreal. He and Vicky Jarvis originated the Canadian Chemical Crystallography Workshop and the Canadian Materials Diffraction Workshop, and he teaches at these and the Canadian Powder Diffraction Workshop each year. He is also a co-author of the MAX3D program for the visualization of 3D diffraction patterns.